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Celulele canceroase devin ''canibale'' pentru a putea supravieţui chimioterapiei (studiu)

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- It happens the same everywhere around the world. (The Yard)

-I was invited somwhere in the wold, by a friend, my friend make a lot of promisses. Promises which prefer to forget, now. He live in a house with several apartaments, with a shared courtyard. Since I am hosted here, and waith the promises come true, I see the same general dirt in the yard. - Time passes by working better. I said, and I grabbed with enthusiasm to clean. Gathering dried laves, collecting papers, sweep. A Lady , neighbour Lady, asked me, very surprised what I doing there . - Cleaning the yadr. I answered. - Because we get a lot of dirt in the house. - Yes she sayd. And she explained that the man who is responsable with cleaning dose not do his job. The inhabitants of the house will make a meeting, and they will solve the problem. This very ugly problem . - OK. I said, she left. While I cleaning the yard, I think what will happen now ? The man will be judjed, they will fire him . However, it is his duty. Or not ? I have collected numerous remnants of cigarettes, Ice cream papers, ...... Did we not have to respect the work of others ? - I asked myself. Why ?. 

- Maybe the man can not chase after everyone. And it looked like in the yard, is a competition. - Who throw more rubbish. It is easy to criticize, it is harder to help. For example: - do not throw trash in the yard. But, it is easier to judge . - This happen every day wherever in the world. We are different characters, but the same different caracters live worldwide, the only thing that is different is the country in which we live. Or where we come from. Richer country , or a poorer country. And it's good, they are poor countries, - We have forgotten how cleaning. They will do it. While I was cleaning, listening the album, The Wall (Pink Floyd and it fit well in the current situation.) I just remembered, my friend promises . - " Our home , our food , our work , life together ........." Yeah sure . Now my friend says he promised to much. In other words . Get out. Or , I 'm bored with this new toy. Thank God that we are not all the same. We are different characters. I have favorite quotes : - "Accept the things to Which fate binds you, and love the people with Whom fate brings you together , but do so with all your heart . " .... "Where I live if someone Gives you a hug it's from the heart . "...To tell the truth, I was very well tolerated in this house, I did not missed anything, for a time. Now my days are counted here, I think I've become an unwanted ghost. A sort trash. Why people do not understand, that promises must be respected. As a man's life may depend on promises. Those who are educated in the virtual world, forget the true world. - "Love all, trust a few, do wrong to none." - - I do not want to hurt anyone, especially my friends, my friend. I keep the pleasant memories. (Because it was. I was accepted and helped for a while. I must admit that. ) My friend wants to help me, even now. He'll tolerate my presence in the area. What great luck I have. Stupidity and reign are paid. I feel it now. - I continue to clean away, maybe I'll manage to clean, in my soul and in others soul. Maybe. But life will never forgive this fatal mistake, why I trusted my friend. Why ? - Because things are linked together, promise and trust. Okay, time to go, I do not accept any false help, and promises more. I'm going to clean in to another world.


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Celulele canceroase devin ''canibale'' pentru a putea supravieţui chimioterapiei (studiu)

Celulele canceroase devin ''canibale'' pentru a putea supravieţui chimioterapiei (studiu)

Celulele canceroase devin ''canibale'' pentru a putea supravieţui chimioterapiei (studiu)

Unele celule canceroase îşi devorează semenele vecine pentru a putea supravieţui chimioterapiei şi să-şi reînnoiască atacul chiar şi după încheierea tratamentului, potrivit unui articol publicat marţi de revista Journal of Cell Biology, relatează EFE.

Potrivit studiului, chimioterapia nu ucide aceste celule canceroase care, în general, încetează să prolifereze, dar intră într-o stare latentă şi metabolic activă, cunoscută ca "senescenţă".

Medicamentele folosite în chimioterapie, precum Doxorubicina sau Hidroxil daunorubicina sunt antibiotice care atacă acidul dezoxiribonucleic (ADN) al celulelor canceroase, însă cele care supravieţuiesc tratamentului pot provoca noi tumori.

Acesta este procesul, de exemplu, al cancerului mamar în care intervine moştenirea unei copii anormale a genei TP53.

Echipa cercetătoarei Crystal Tonnessen-Murray de la Facultatea de Medicină a Universităţii Tulane, din Louisiana, a descoperit că după tratamentul cu Doxorubicină sau alte medicamente folosite în chimioterapie, celulele cancerului mamar devin "senescente" şi le înconjoară pe cele din vecinătatea lor.

Studiul include şi o serie de clipuri care arată comportamentul surprins de cercetători şi care nu se regăseşte doar la celulele canceroase cultivate în laborator ci şi la tumorile cultivate la şoarecii cobai.

Astfel, celulele cancerului la plămân şi oase sunt capabile să-şi devoreze vecinele după ce devin "senescente".

Mecanismul prin care celulele "senescente" operează include activarea unui grup de gene care se găsesc de obicei în globulele albe, fagocitele, din sânge implicate în combaterea microbilor care invadează organismul.

Celulele canibale îşi devorează vecinele dizolvându-le în lisosomi (agenţi ai fenomenului de digestie intracelulară) care se menţin foarte activi în celulele "senescente". Potrivit cercetătorilor, această voracitate le permite "senescentelor" să rămână vii şi să supravieţuiască un timp mai îndelungat, decât celulelor canceroase care nu îşi devorează semenele.

Această devorare a vecinelor lor le oferă celulelor "senescente" energia de care au nevoie pentru a putea supravieţui asaltului medicamentelor şi a genera factorii ce determină reapariţia tumorii, încheie studiul.

AGERPRES/(AS-autor: Mihaela Nicolaescu, editor: Mariana Ionescu, editor online: Adrian Dădârlat)

2019-09-18 17:53:18


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